Released in conjunction with 3D versions on consoles, Donald Duck's adventure on the Game Boy Color is a traditional side-scrolling platformer.

The evil magician Merlock has kidnapped Duckburg Times reporter Daisy Duck. Donald Duck turns to Gyro Gearloose for help, who suggests using his latest invention: a powerful teleporter. Unfortunately, Merlock learns of their plans and steals the blueprints to the device. Now Gyro uses the unfinished machine to teleport Donald to various locations, where he is to find the parts of the blueprints, so he may confront Merlock and rescue Daisy.